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leptin 2

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bioimaging 1

cancer diagnosis and treatment 1

carbohydrate 1

central secretory 1

energy balance 1

glyco-functionalised QD 1

intestinal I/R 1

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Leptin signaling and leptin resistance

Yingjiang Zhou, Liangyou Rui

Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 207-222 doi: 10.1007/s11684-013-0263-5

Abstract:

Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of energyLeptin deficiency or genetic defects in the components of the leptin signaling pathways cause obesityLeptin controls energy balance and body weight mainly through leptin receptor b (LEPRb)-expressing neuronsLeptin resistance is the key risk factor for obesity.This review is focused on recent advance about leptin action, leptin signaling, and leptin resistance

Keywords： leptin signaling leptin receptor energy balance leptin resistance obesity

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Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene

Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG

Frontiers of Medicine 2009, Volume 3, Issue 1, Pages 57-60 doi: 10.1007/s11684-009-0003-z

Abstract: Leptin resistance is a main mechanism of acquired childhood obesity, and the suppression of long formof leptin receptor (OBRb) gene expression in diet-induced obese rats indicates that the down-regulationof OBRb gene expression plays a pivotal role in the mechanism of leptin resistance.

Keywords： receptors leptin RNA interference lentivirus vector

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The change of serum leptin and its relationship with platelet membrane glycoprotein Ib in patients with

XIA Dasheng, SONG Yanqiu, LI Chao, ZHANG Feng, WEI Minxin

Frontiers of Medicine 2007, Volume 1, Issue 4, Pages 352-355 doi: 10.1007/s11684-007-0067-6

Abstract: The aim of this paper was to investigate the change of serum leptin and its relationship with plateletSerum leptin was detected by enzyme linked immunosorbent assay.Multifactorial stepwise regression analysis showed that serum leptin in CHD patients was independentlyLogistic analysis demonstrated that serum leptin was independently correlated with the risk of CHD (leptin could affect blood platelet activation.

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Effect of intestinal ischemia/reperfusion injury on leptin and orexin-A levels

LIN Ji, YAN Guangtao, HAO Xiuhua, ZHANG Kai, GAO Xiaoning, LIAO Jie

Frontiers of Medicine 2007, Volume 1, Issue 1, Pages 87-92 doi: 10.1007/s11684-007-0017-3

Abstract: The aim of this paper is to explore the effect of intestinal ischemia/reperfusion (I/R) injury on leptinand orexin-A levels in peripheral blood and central secretory tissues, and to examine the roles of leptinRadioimmunoassay was employed to detect the levels of leptin in serum and adipose tissue and orexin-A, adipose leptin levels of I60´R30´ and I60´R90´ decreased, and adipose leptin in I60´R360´ group increasedLeptin and orexin-A respond to intestinal I/R injury in a time-dependent manner, with leptin responding

Keywords： significant difference intestinal I/R transcriptase-polymerase metabolic central secretory

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Glyco-functionalised quantum dots and their progress in cancer diagnosis and treatment

Jayshree Ashree, Qi Wang, Yimin Chao

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 3, Pages 365-377 doi: 10.1007/s11705-019-1863-7

Abstract: Despite all major breakthroughs in recent years of research, we are still unsuccessful to effectively diagnose and treat cancer that has express and metastasizes. Thus, the development of a novel approach for cancer detection and treatment is crucial. Recent progress in Glyconanotechnology has allowed the use of glycans and lectins as bio-functional molecules for many biological and biomedical applications. With the known advantages of quantum dots (QDs) and versatility of carbohydrates and lectins, Glyco-functionalised QD is a new prospect in constructing biomedical imaging platform for cancer behaviour study as well as treatment. In this review, we aim to describe the current utilisation of Glyco-functionalised QDs as well as their future prospective to interpret and confront cancer.

Keywords： carbohydrate leptin glyco-functionalised QD bioimaging cancer diagnosis and treatment